Adrenocorticotropic Hormone
How It Is Done
The health professional drawing blood will:
- Wrap an elastic band around your upper arm to stop the flow of blood. This makes the veins below the band larger so it is easier to put a needle into the vein.
- Clean the needle site with alcohol.
- Put the needle into the vein. More than one needle stick may be needed.
- Attach a tube to the needle to fill it with blood.
- Remove the band from your arm when enough blood is collected.
- Put a gauze pad or cotton ball over the needle site as the needle is removed.
- Put pressure to the site and then put on a bandage.
How It Feels
The blood sample is taken from a vein in your arm. An elastic band is wrapped around your upper arm. It may feel tight. You may feel nothing at all from the needle, or you may feel a quick sting or pinch.
Risks
There is very little chance of a problem from having blood sample taken from a vein.
- You may get a small bruise at the site. You can lower the chance of bruising by keeping pressure on the site for several minutes.
- In rare cases, the vein may become swollen after the blood sample is taken. This problem is called phlebitis. A warm compress can be used several times a day to treat this.
- Ongoing bleeding can be a problem for people with bleeding disorders. Aspirin, warfarin (Coumadin), and other blood-thinning medicines can make bleeding more likely. If you have bleeding or clotting problems, or if you take blood-thinning medicine, tell your doctor before your blood sample is taken.
- Bruising may be more likely in people with high ACTH and cortisol levels.
Results
An adrenocorticotropic hormone test measures the level of adrenocorticotropic hormone (ACTH) in the blood.
Results of an ACTH test are usually available in 4 to 6 days.
Normal
The normal values listed here-called a reference range-are just a guide. These ranges vary from lab to lab, and your lab may have a different range for what’s normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab.
| 6 a.m. to 8 a.m. | |
|---|---|
| 6 p.m. to 11 p.m. | Less than 50 pg/mL or less than 11 pmol/L |
High values
High levels of ACTH may be caused by:
- Emotional or physical stress (such as recent surgery or severe pain).
- Diseases such as Addison's disease, Cushing's disease, or a tumor in the adrenal glands or the pituitary gland.
Low values
Low levels of ACTH may be caused by:
- Damage to the pituitary gland from surgery, radiation, stroke, head injury, or a tumor.
- An increased amount of cortisol from a tumor in the adrenal glands (Cushing's syndrome).
- Corticosteroid medicines.
| Condition | ACTH | Cortisol |
|---|---|---|
Cushing's disease | High | High |
Cushing's syndrome | Low | High |
ACTH made outside the pituitary gland | High | High |
High | Low | |
Hypopituitarism | Low | Low |
WebMD Medical Reference from Healthwise
