Adrenoleukodystrophy

Important
It is possible that the main title of the report Adrenoleukodystrophyis not the name you expected.

Synonyms

X- ALD
Addison Disease with Cerebral Sclerosis
Adrenomyeloneuropathy
ALD
AMN
Bronze Schilder Disease
Melanodermic Leukodystrophy
Schilder Disease
Siemerling-Creutzfeldt Disease
Sudanophilic Leukodystrophy

Disorder Subdivisions

None

General Discussion

Adrenoleukodystrophy is an X-linked recessive genetic disorder caused by an abnormality in the ABCD1 gene on the X chromosome. This condition affects the white matter of the nervous system and the adrenal cortex. Some affected individuals have adrenal insufficiency, which means that reduced amounts of certain hormones such as adrenaline and cortisol are produced, leading to abnormalities in blood pressure, heart rate, sexual development and reproduction. Some of those affected experience serious neurological problems that can affect mental function and lead to disability and reduced life span. This condition has been categorized into six types based on symptoms and age of onset: childhood cerebral ALD, adolescent cerebral ALD, adrenomyeloneuropathy, adult cerebral ALD, adrenal insufficiency only and ALD that occurs in females.

Resources

CLIMB (Children Living with Inherited Metabolic Diseases)
Climb Building
176 Nantwich Road
Crewe
Intl
CW2 6BG
United Kingdom
Tel: +44 870 7700 325
Fax: +44 870 7700 327
info@climb.org.uk
http://www.CLIMB.org.uk

Kennedy Krieger Institute
707 North Broadway
Baltimore
MD
21205
Tel: (443)923-9200
Fax: (443)923-9405
800: (800)873-3377
TDD: (443)923-9400
webmaster@kennedykrieger.org
http://www.kennedykrieger.org

March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains
NY
10605
Tel: (914)428-7100
Fax: (914)997-4763
800: (888)663-4637
Askus@marchofdimes.com
http://www.marchofdimes.com

The Arc (a national organization on mental retardation)
1010 Wayne Ave
Suite 650
Silver Spring
MD
20910
Tel: (301)565-3842
Fax: (301)565-3843
800: (800)433-5255
TDD: (817)277-0553
info@thearc.org
http://www.thearc.org/

United Leukodystrophy Foundation
2304 Highland Drive
Sycamore
IL
60178
Tel: (815)895-3211
Fax: (815)895-2432
800: (800)728-5483
office@ulf.org
http://www.ulf.org/

ELA - European Association against Leukodystrophies
2, rue Mi-les-Vignes
Laxou
54520
France
Tel: 33 383 30 93 34
Fax: 33 383 30 00 68
ela@ela-asso.com
http://www.ela-asso.com

National Institute of Neurological Disorders and Stroke (NINDS)
31 Center Drive
8A07
Bethesda
MD
20892-2540
Tel: (301)496-5751
Fax: (301)402-2186
800: (800)352-9424
braininfo@ninds.nih.gov
http://www.ninds.nih.gov/

ALD Family Support Trust
4 Morley House
320 Regent Street
London
Intl
W1B 3BB
United Kingdom
Tel: 020-7631-3336
Fax: 020-7631-3336
info@aldfst.org.uk
http://www.aldfst.org.uk

Hunter's Hope Foundation, Inc.
PO Box 643
3859 N. Buffalo Street
Orchard Park
NY
14127
Tel: (716)667-1200
Fax: (716)667-1212
800: (877)984-4673
info@huntershope.org
http://www.huntershope.org

MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay
WI
54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
800: (877)336-5333
mums@netnet.net
http://www.netnet.net/mums/

Australian Leukodystrophy Support Group, Inc.
10 Mitchell Street
Mentone, Victoria
3194
Australia
Tel: 0011(03)9584 7070
Fax: 0011(03)9583 4379
leuko@vicnet.net.au
http://www.alds.org.au

Fight ALD
P.O. Box 3318
Vista
CA
92085
info@fightald.org
http://www.fightald.org

Zellweger Baby Support Network
1852 Iron Horse Loop
Spearfish
SD
57783
Tel: (605)642-2072
Fax: (605)642-7525
pamfreeth@zbsn.org
http://www.zbsn.org and http://groups.msn.com/ZellwegerBabySupportNetwork/welcometozbsn1.msnw

For a Complete Report:

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated: 8/8/2007
Copyright 1985, 1986, 1988, 1989, 1990, 1993, 1994, 1997, 1998, 1999, 2006, 2007 National Organization for Rare Disorders, Inc.

WebMD Medical Reference from the National Organization of Rare Disorders

Last Updated: August 08, 2007

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