Mikulicz Syndrome

Important
It is possible that the main title of the report Mikulicz Syndromeis not the name you expected.

Synonyms

Dacryosialoadenopathia
Dacryosialoadenopathy
Mikulicz Syndrome
Mikulicz-Radecki Syndrome
Mikulicz-Sjogren Syndrome
von Mikulicz Syndrome

Disorder Subdivisions

None

General Discussion

Mikulicz syndrome is a chronic condition characterized by the abnormal enlargement of glands in the head and neck, including those near the ears (parotids) and those around the eyes (lacrimal) and mouth (salivary). The tonsils and other glands in the soft tissue of the face and neck may also be involved. Although the disorder is almost always described as benign, it always occurs in association with another underlying disorder such as tuberculosis, leukemia, syphilis, Hodgkin’s disease, lymphosarcoma, Sjogren syndrome, or lupus (SLE). People who have Mikulicz syndrome are at heightened risk for developing lymphomas.

Some people with Mikulicz syndrome may experience recurring fevers. The fever may be accompanied by dry eyes, diminished tear production (lacrimation), and inflammation of various parts of the eyes (uveitis). Lacrimal gland enlargement, parotid gland enlargement, dry mouth and dry eyes are the classic signs.

The exact cause of Mikulicz syndrome is not known. Some scientists believe that Mikulicz syndrome should be considered a form of Sjogren syndrome.
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Resources

American Autoimmune Related Diseases Association, Inc.
22100 Gratiot Avenue
Eastpointe
MI
48021-2227
Tel: (586)776-3900
Fax: (586)776-3903
800: (800)598-4668
aarda@aarda.org
http://www.aarda.org/

Sjogren's Syndrome Foundation, Inc.
8120 Woodmont Ave
Suite 530
Bethesda
MD
20814
Tel: (301)718-0300
Fax: (301)718-0322
800: (800)475-6473
http://www.sjogrens.org

NIH/National Oral Health Information Clearinghouse
1 NOHIC Way
Bethesda
MD
20892-3500
USA
Tel: (301)402-7364
Fax: (301)907-8830
TDD: (301)656-7581
nohic@nidcr.nih.gov
http://www.nohic.nidcr.nih.gov

AutoImmunity Community
Tel: (919) 552-9057
bandrews@autoimmunitycommunity.org
http://autoimmunitycommunity.org

For a Complete Report:

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated: 4/18/2008
Copyright 1986, 1994, 2003 National Organization for Rare Disorders, Inc.

WebMD Medical Reference from the National Organization of Rare Disorders

Last Updated: April 18, 2008

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