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Osteogenesis Imperfecta
Important
It is possible that the main title of the report Osteogenesis Imperfectais not the name you expected.
Synonyms
- Brittle Bone Disease
- Ekman-Lobstein Disease
- Lobstein Disease (Type I)
- OI
- Vrolik Disease (Type II)
Disorder Subdivisions
- Osteogenesis Imperfecta Type I
- Osteogenesis Imperfecta Type II
- Osteogenesis Imperfecta Type III
- Osteogenesis Imperfecta Type IV
General Discussion
Osteogenesis Imperfecta (OI) is a group of rare disorders affecting the connective tissue and characterized by extremely fragile bones that break or fracture easily (brittle bones), often without apparent cause. The specific symptoms and physical findings associated with OI vary greatly from case to case. The severity of OI also varies greatly, even among individuals of the same family. OI may be a mild disorder or may result in severe complications. Four main types of OI have been identified. OI type I is the most common and the mildest form of the disorder. OI type II is the most severe. In most cases, the various forms of osteogenesis imperfecta are inherited as autosomal dominant traits.
Resources
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains
NY
10605
Tel: (914)428-7100
Fax: (914)997-4763
800: (888)663-4637
Askus@marchofdimes.com
http://www.marchofdimes.com
Osteogenesis Imperfecta Foundation, Inc.
804 West Diamond Avenue
Suite 210
Gaithersburg
MD
20878
USA
Tel: (301)947-0083
Fax: (301)947-0456
800: (800)981-2663
bonelink@oif.org
http://www.oif.org
NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
1 AMS Circle
Bethesda
MD
20892-3675
USA
Tel: (301)495-4484
Fax: (301)718-6366
800: (877)226-4267
TDD: (301)565-2966
NIAMSinfo@mail.nih.gov
http://www.niams.nih.gov/Health_Info
Whyte, Michael P., M.D.
Metabolic Research Unit
Shriners' Hospital for Crippled Children
2001 S. Linbergh Blvd.
St. Louis
MO
63131
Tel: (314)532-3600Canadian Osteogenesis Imperfecta Society
208 Ramona Blvd
Markham
Ontario
L3P 2K8
Canada
Tel: 905-294-5340
rkhayes@ccat.on.ca
http://www.oif.org
Children's Brittle Bone Foundation
7701 95th St
Pleasant Prairie
WI
53158
Tel: (866)694-2223
Fax: (262)947-0724
info@cbbf.org
http://www.cbbf.org
NIH/National Institute of Child Health and Human Development
31 Center Dr
Building 31, Room 2A32
MSC2425
Bethesda
MD
20892
Tel: (301)496-5133
Fax: (301)496-7101
http://www.nih.gov/hichd/
MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay
WI
54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
800: (877)336-5333
mums@netnet.net
http://www.netnet.net/mums/
Sjældne Diagnoser / Rare Disorders Denmark
Frederiksholms Kanal 2, 3rd Floor
Copenhagen K
1220
Denmark
Tel: 45 33 14 00 10
Fax: 45 33 14 55 09
mail@sjaeldnediagnoser
http://www.raredisorders.dk
Let Them Hear Foundation
1900 University Ave #101
East Palo Alto
CA
94303
Tel: (650)462-3143
Fax: (650)462-3143
800: (877)735-2929
info@letthemhear.org
http://www.letthemhear.org
European Skeletal Dysplasia Network (ESDN)
Wellcome Trust Centre for Cell-Matrix Research
Faculty of Life Sciences
University of Manchester
Michael Smith Building, Oxford Road
Manchester
M13 9PT
UK
Tel: 44 161 275 5642
Fax: 44 161 275 5082
info@esdn.org
http://www.esdn.org
For a Complete Report:
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org
Last Updated: 1/3/2007
Copyright 1984, 1985, 1986, 1987, 1988, 1990, 1992, 1996, 1997, 1999, 2001, 2003, 2007 National Organization for Rare Disorders, Inc.
WebMD Medical Reference from the National Organization of Rare Disorders
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