Triplo X Syndrome

Important
It is possible that the main title of the report Triplo X Syndromeis not the name you expected.

Synonyms

Triple X Syndrome
47,XXX Syndrome
47,XXX Karyotype
47,XXX Chromosome Constitution
Trisomy X

Disorder Subdivisions

None

General Discussion

Triplo X Syndrome is a chromosomal abnormality that affects females. Females normally have two X chromosomes; however, those with Triplo X Syndrome carry three X chromosomes (trisomy X) in the nuclei of body cells. No specific pattern of symptoms and malformations (phenotype) has been found to be associated with this abnormal chromosomal make-up (i.e., 47,XXX karyotype). Many affected females appear to have no or very few associated symptoms, while others may have various abnormalities.

However, investigators indicate that Triplo X Syndrome is a relatively common cause of learning difficulties, particularly language-based disabilities (e.g., dyslexia), in females. Evidence suggests that affected females typically have normal intelligence with IQs that tend to be lower than that of their brothers and sisters (siblings). Mental retardation rarely occurs. Infants and children with Triplo X Syndrome may tend to have delayed acquisition of certain motor skills and delayed language and speech development.

Affected females often are of tall stature. According to researchers, although sexual development and fertility are usually normal, some may have delayed puberty and/or fertility problems. In addition, in some cases, certain physical abnormalities have been reported, such as a relatively small head, vertical skin folds that may cover the eyes' inner corners (epicanthal folds), and/or other findings. Triplo X Syndrome results from errors during the division of reproductive cells in one of the parents.
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Resources

March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains
NY
10605
Tel: (914)428-7100
Fax: (914)997-4763
800: (888)663-4637
Askus@marchofdimes.com
http://www.marchofdimes.com

National Dissemination Center for Children with Disabilities
P.O. Box 1492
Washington
D.C.
20013
USA
Tel: (202)884-8200
Fax: (202)884-8441
800: (800)695-0285
TDD: (800)695-0285
nichcy@aed.org
http://www.nichcy.org

National Center for Learning Disabilities
381 Park Avenue South
#1401
New York
NY
10016
Tel: (212)545-7510
Fax: (212)545-9665
800: (888)575-7373
help@ncld.org
http://www.ld.org

Learning Disabilities Association of America
4156 Library Road
Pittsburgh
PA
15234-1349
Tel: (412)341-1515
Fax: (412)344-0224
800: (888)300-6710
info@ldaamerica.org
http://www.ldaamerica.org

International Dyslexia Association
Chester Building
Suite 382
8600 LaSalle Road
Baltimore
MD
21286-2044
USA
Tel: (410)296-0232
Fax: (410)321-5069
800: (800)222-3123
info@interdys.org
http://www.interdys.org

UNIQUE - Rare Chromosome Disorder Support Group
P.O. Box 2189
Caterham
Surrey
Intl
CR3 5GN
United Kingdom
Tel: 44 0 1883 330766
Fax: 44 0 1883 330766
info@rarechromo.org
http://www.rarechromo.org

MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay
WI
54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
800: (877)336-5333
mums@netnet.net
http://www.netnet.net/mums/

Klinefelter Syndrome & Associates (KS&A)
11 Keats Court
Coto de Caza
CA
92679
Tel: (888)999-9428
Fax: (949)858-3443
800: (888)999-9428
khenry@genetic.org
http://www.genetic.org

For a Complete Report:

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated: 5/8/2008
Copyright 1995, 1996, 1997, 1998, 2001 National Organization for Rare Disorders, Inc.

WebMD Medical Reference from the National Organization of Rare Disorders

Last Updated: May 08, 2008

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